Spearheaded by the Portland Art Museum and Pixel Arts Game Education, the Mythos Challenge is a collaboration between youth, cultural institutions, and community stakeholders across Oregon. The Challenge brings together players from local STEAM (Science, Technology, Engineering, Arts, and Math) organizations to create a city-wide network of in-person meet-ups and online initiatives.

The Mythos Challenge is divided into three parts: a Youth Council, Game Competition, and Workshop Series.